In vitro Toxicology

The Toxicological Laboratory has been working on the animal use reduction and, in 2019, .opened its In vitro Toxicological Laboratory. Comparative studies has shown a similarity between results of in vivo and in vitro studies, making this implementation safe and viable.

Below, a relation of In vitro studies following OECD normative:


Genotoxicity and mutagenicity studies

Genotoxicity and mutagenicity studies are performed to predict genotoxic and mutagenic potential of a specific substance, through gene mutation, chromosomal damage or DNA lesion evaluation, which are important to adverse outcome induction in human health, such as cancer.

The GLP 0021 scope can be consulted at INMETRO webpag