{"id":266,"date":"2021-06-24T15:21:54","date_gmt":"2021-06-24T18:21:54","guid":{"rendered":"https:\/\/www.planteclab.com\/en\/\/?page_id=266"},"modified":"2022-01-14T00:46:22","modified_gmt":"2022-01-14T03:46:22","slug":"toxicologia-in-vitro","status":"publish","type":"page","link":"https:\/\/www.planteclab.com\/en\/servicos\/toxicologia-in-vitro\/","title":{"rendered":"In vitro Toxicology"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">The Toxicological Laboratory has been working on the animal use reduction and, in 2019, .opened its In vitro Toxicological Laboratory. Comparative studies has shown a similarity between results of in vivo and in vitro studies, making this implementation safe and viable.<\/span><\/p>\n<h5><strong>Below, a relation of In vitro studies following OECD normative:<\/strong><\/h5>\n<ul>\n<li>Bovine corneal opacity and permeability test (BCOP) (OECD 437);<\/li>\n<li>Isolated chicken eye test &#8211; ICE (OECD 438);<\/li>\n<li>Short term exposure in vitro for eye risk evaluation &#8211; STE (OECD 491);<\/li>\n<li>In vitro skin corrosion test. Assay with reconstructed human epidermis (RHE) (OECD 431);<\/li>\n<li>In vitro skin irritation test. Assay with reconstructed human epidermis (RHE)  (OECD 439);<\/li>\n<li>Local lymph node assay: BRDU-ELISA (OECD 442B);<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h5><b>Genotoxicity and mutagenicity studies<\/b><\/h5>\n<p><span style=\"font-weight: 400;\">Genotoxicity and mutagenicity studies are performed to predict genotoxic and mutagenic potential of a specific substance, through gene mutation, chromosomal damage or DNA lesion evaluation, which are important to adverse outcome induction in human health, such as cancer.<\/span><\/p>\n<ul>\n<li>Micronucleous test in vitro &#8211; MNVit  (OECD 487)<\/li>\n<li>Reversal gene mutation test (Ames Test)  (OECD 471)<\/li>\n<li>In vitro mammalian cell gene mutation assay using cells from mouse lymphoma &#8211; MLA (OECD 490)<\/li>\n<\/ul>\n<p><strong><span style=\"font-weight: 400;\">The GLP 0021 scope can be consulted at INMETRO webpag<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Toxicological Laboratory has been working on the animal use reduction and, in 2019, .opened its In vitro Toxicological Laboratory. Comparative studies has shown a similarity between results of in vivo and in vitro studies, making this implementation safe and viable. Below, a relation of In vitro studies following OECD normative: Bovine corneal opacity and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":368,"parent":81,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-266","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/pages\/266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/comments?post=266"}],"version-history":[{"count":13,"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/pages\/266\/revisions"}],"predecessor-version":[{"id":433,"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/pages\/266\/revisions\/433"}],"up":[{"embeddable":true,"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/pages\/81"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/media\/368"}],"wp:attachment":[{"href":"https:\/\/www.planteclab.com\/en\/wp-json\/wp\/v2\/media?parent=266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}